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The accumulation of ROS damages cochlear cells, particularly OHCs, leading to apoptosis and subsequent auditory dysfunction

5.2 Microbial metabolites with neuroprotective roles Microbial metabolites serve as important biochemical mediators between the gut and the CNS, regulating many neuroprotective pathways that oppose neuroinflammation and neuronal vulnerability

or anabolic the building up (biosynthesis) of compounds (such as proteins, carbohydrates, lipids, and nucleic acids)